GI tolerability was assessed at each study visit during the initial 180-min period and 24 h post dose using a 4-point Likert scale (none, mild, moderate or severe) to describe symptoms. The number of bowel movements was counted at each study visit until 24 h post dose for the different treatment groups. Consistency of stool was graded based on the Bristol Stool Form Scale (BSFS)[22] (type 1 = separate hard lumps, like nuts (hard to pass); type 2 = sausage-shaped but lumpy; type 3 = like a sausage with cracks on its surface; type 4 = like a sausage or snake, smooth and soft; type 5 = soft blobs with clear-cut edges, passed easily; type 6 = fluffy pieces with ragged edges, a mushy stool; type 7 = liquid, no solid pieces) with types 1 and 2 reflecting severe and mild constipation, types 3 to 5 showing normal stool, and types 6 and 7 reflecting mild and severe diarrhea.
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With regard to safety and tolerability, the GI symptoms experienced by the participating subjects after single oral lactulose intake are well known. The reported AEs included diarrhea, flatulence, and abdominal discomfort that, as expected, were reported more frequently after intake of the higher lactulose dose. Usually, GI symptoms disappear after some days of lactulose treatment. Most treatment-emergent AEs were mild to moderate in severity, considered to be related to the study treatment, and resolved by the end of the 24 h posttreatment observation period. Overall, lactulose was well tolerated, and no unexpected safety issues were identified.
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The remaining rounds were stored inside safe containers on the hull floor.[38] A new short receiver coaxial machine gun was designed for the M60 tank. This was the 7.62mm M73/T197E2 which replaced the .30 caliber M37 used on the M48A2. It had 2,000 rounds of ammunition.[43] They had a reputation for jamming. After working to correct this, they were redesignated as the M73A1 in 1970.
The ammunition load for the main gun was increased to 63 rounds. Round storage was distributed between the turret bustle, where 15 ready rounds of various types were stowed and accessible for the loader, and the rest were stored inside safe containers on the hull floor.[38]
Over the period of M60A1 tank production, several essential engineering changes were incorporated. Many of these miscellaneous changes were to improve the system safety, reliability, maintainability and increase mission performance. The M60A1 Tank Hull/Turret Product Improvement Plan (PIP) Update Kit includes those items that could not be readily identified with basic major product improvements and to incorporate essential engineering changes that had occurred during M60A1 tank production. The update program included engineering changes and minor product improvements which were not part of specific product improvements, but were required to upgrade early vintage M60A1 tanks up to the current M60A1(RISE) production configuration.[52] Additionally the Hull PIP Update Kit was applied to the M48A5.
It was also discovered that structural cracks in the barrel occurred after several missile firings. This defect was traced to a flaw in the missile's longitudinal key, which fitted into a keyway inside the gun barrel. It was determined that a less deep key would significantly extend the service life of the barrel.[74]
The M60 Phoenix Project was Jordan's modular upgrade of the M60A3TTS to better address both immediate and emerging threats to the M60MBT. The tank is armed with a RUAG Land Systems L50 120 mm smoothbore Compact Tank Gun (CTG) with a firing rate of 6-10 rounds per minute. 20 ready rounds are stored in the turret bustle.[106] The M21 FCS is replaced with Raytheon's Integrated Fire Control System (IFCS). The system consists of an eye safe laser rangefinder, second generation night sight, digital ballistic computer, cant sensors and a MIL-STD 1553 data bus. The M10 ballistic drive is upgraded with a fully electrical superelevation resolver.[107]
The Raytheon Integrated Fire Control System (IFCS) integrating an eye safe laser rangefinder, second generation gunner's night sight, digital ballistic computer, cant sensors, a fully electrical superelevation resolver and a MIL-STD 1553 data bus, giving the system capabilities similar to the M1AD standard. Other turret upgrades offered are the Curtis-Wright Gun Turret Drive and replacing the M19 cupola with a Hitrole remote controlled weapon system, that enables 360 panoramic surveillance from a secure position inside the tank armed with a M2HB .50cal machine gun.[111]
The turret has been refitted with a new set of hydraulic and servo control improving performance. The rest of the vehicle is completely overhauled including the torsion bars, brakes, fuel supply, electric system, wheels, seals, paint, and smoke grenades. The vehicle has also been retrofitted with the Automatic Fire and Explosion Sensing and Suppression System (AFSS). It is equipped with the LOTHAR gun sight, DNVS-4 Driver's Night Vision Sight and TURMS digital fire control system. a daytime TV camera, and an eye-safe Laser range finder. IED jamming systems and a laser warning receiver systems developed by Leonardo are optionally offered.[114]
M60 tanks participated in Operation Urgent Fury in 1983. Marines from G Company of the US 22nd Marine Assault Unit equipped with Amphibious Assault Vehicles and four M60A1 tanks landed at Grand Mal Bay on October 25 and relieved the Navy SEALs the following morning, allowing Governor Scoon, his wife, and nine aides to be safely evacuated. The Marine tank crews faced sporadic resistance, knocking out a BRDM-2 armored car. G Company subsequently overwhelmed the Grenadian defenders at Fort Frederick.[120] The 1st Battalion, 8th Marine Regiment deployed with M60A1s to Beirut and were present during the subsequent October 23 Beirut barracks bombing near the Beirut International Airport during the ongoing Lebanese Civil War.[121]
M60A1s have been historically used for ground force adversarial work during Exercise Red Flag[122] as well as in close air support trials with the F-16 at Nellis Air Force Base, Nevada in the 1980s. During Operation Desert Storm in the Gulf War of 1991, at least one US Air Force unit was equipped with M60 tanks. The 401st TFW (P), deployed to Doha, Qatar had two M60A3 tanks for use by explosives ordnance disposal personnel. It was planned that using the tanks would allow the EOD crews to remove unexploded ordnance from tarmac runway and taxiway surfaces with increased safety.[123]
Standard safety features for all 2015 Mercedes-Benz M-Class models include antilock brakes, traction and stability control, PreSafe (which can identify an imminent crash and automatically take measures to secure occupants), hill-start assist and hill-descent control, active front head restraints, a driver inattention warning system, a collision warning system, front and rear side airbags, side curtain airbags and a driver knee airbag. The mbrace2 communications system includes automatic collision notification, an SOS button, stolen vehicle location, geo-fencing, alarm notification and remote door lock/unlock. A rearview camera is standard on the ML 63 and optional on all other versions.
The ML250 (replaces last year's ML350 Bluetec) comes standard with 18-inch wheels, adaptive suspension dampers, LED running lights and taillights, automatic wipers, a sunroof, roof rails and a power liftgate. Inside, you'll find dual-zone automatic climate control, cruise control, wood interior trim, a manual tilt-and-telescoping leather-wrapped steering wheel, eight-way power front seats (with four-way power lumbar adjustment), heated front seats, reclining 60/40-split folding rear seats, MB-Tex premium vinyl upholstery (leather is optional), the COMAND electronics interface (with 7-inch color display), Mercedes' mbrace2 communications system (includes smartphone app integration), Bluetooth phone and audio connectivity and an eight-speaker sound system with HD radio, a USB port and an auxiliary audio jack. There are also numerous standard safety features listed below under Safety.
Standard safety features include antilock brakes (with brake assist, brake fade compensation, brake drying and a brake stand-by feature), stability and traction control, front-seat side airbags, front knee airbags, side curtain airbags and active front head restraints. In Edmunds brake testing, the 750i with the Sport package came to a stop in a very short 112 feet.
Optional safety features include adaptive cruise control, rear- and sideview cameras and infrared night vision with pedestrian detection that dis